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KMID : 0359420060240020219
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Korean Journal of Sports Medicine
2006 Volume.24 No. 2 p.219 ~ p.228
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Gender Specific Associations of the β3-Adrenergic Receptor Gene Mutation with Obesity-Related Phenotypes in Korean Adults
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Kim Ki-Jin
Hong Chang-Bae
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Abstract
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The aim of this study was to investigate whether the β-3 adrenergic receptor gene mutation was gender-specifically associated with obesity-related phenotypes in Korean adults. Body mass index(BMI), body fat, skinfold thickness, body circumference, and intra-abdominal fat area by computerized tomography(CT), and health related physical fitness were measured using standardized protocols. Mann Whitney u-test with significance levels of p=0.05 were used to test any significant differences in the measured variables between the wild and mutant genotype in the male and female subjects separately. Group analyses showed that in the male subjects only, those with the mutant allele had significantly higher values in axillar skinfold thickness, wrist and ankle circumferences, and LDL-cholesterol, and leptin level than those with wild allele, with no other significant genotype differences. The findings of the current study suggest that the TRP64Arg mutation of the β-3 adrenergic receptor gene may partially contribute to the predisposition to the developemnt of obesity-related phenotypes in the male adults only, but not in the female counterparts.
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KEYWORD
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β3-adrenergic receptor, Gender difference, Obesity, Skinfold thickness
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